Advances in Prostaglandin and Leukotriene Research: Basic by Oliver Werz, Jenny Klemm, Olof Rådmark, Bengt Samuelsson

By Oliver Werz, Jenny Klemm, Olof Rådmark, Bengt Samuelsson (auth.), Bengt Samuelsson, R. Paoletti, Giancarlo C. Folco, E. Granström, S. Nicosia (eds.)

This quantity is the lawsuits of the eleventh overseas convention on Advances in Prostaglandin and Leukotriene learn: uncomplicated technological know-how and New medical purposes, held in Florence, Italy, on June 4-8, 2000, which keeps the culture of protecting either easy and medical points of prostaglandin and leukotriene study.

At this assembly specific emphasis used to be given to the capability program of the unconventional COX-2 inhibitors, the genetics of bronchial asthma with regards to the construction of leukotrienes, and novel mobile networks for the creation of leukotrienes and lipoxins.

Traditionally, as has been performed in previous conferences of this sequence, a large amount of new fabric was once awarded and mentioned this 12 months, with specific realization given to the latest scientific data.

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8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. 22. Soderstrom M, Bolling A, Hammarstrom S. Induction ofleukotriene C4 synthase activity in differentiating human erythroleukemia cells. Biochem Biophys Res Commun 1992; 189:1043-49. Riddick CA, Serio KJ, Hodulik CR, Ring WL, Regan MS, Bigby TD. TGF-beta increases leukotriene C4 synthase expression in the monocyte-like cellline, THP-1. J Immunol 1999; 162:1101-7. , Petersen J, Austen KF. Eosinophils altered phenotypically and primed by culture with granulocyte/macrophage colony-stimulating factor and 3T3 fibroblasts generate leukotriene C4 in response to FMLP.

These data suggest that the translocation and succeeding localization around the nucleus over 5 minutes is important to derive AA from the membrane. (a) (b) Figure 1. Localization of enzymes in a) resting cells and b) activated cells. Figure 2. Localization of cPLA and EGFP fusion protein at each time after the stimulation withPAF. Translocation and Localization of 5-LO and LT A4H Then we prepared CHO cells stably expressing 5-LO and EGFP fusion protein and observed the movement of5-LO triggered by calcium ionophore (Figure 3).

Biol Chern Hoppe Seyler 1995;376:651-60. Weitzel F, Wendel A. Phospholipid hydroperoxide glutathione peroxidase in various mouse organs during selenium deficiency and repletion. J Biol Chern 1993;268:6288-92. Sutherland M, Schewe T, Nigarn S. Biological actions ofthe free acid ofhepoxilin A3 on human neutrophils. Bioehern Pharmacol 1999;59:435-40. Margalit A, Sofer Y, Grossrnan S, Reynaud D, Pace-Asciak CR, Livne AA. Hepoxilin A 3 is the endogenous lipid mediator opposing hypotonie swelling of intact human platelets.

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