Category Archives: Molecular Biology

Non-Coding RNAs: Molecular Biology and Molecular Medicine by Jan Barciszewski, Volker A. Erdmann

By Jan Barciszewski, Volker A. Erdmann

(Landes Bioscience/Eurekah.com) Polish Academy of Sciences, Poznan, Poland. Takes an in-depth examine the functionality of non-coding RNAs and their hyperlink to molecular biology. Discusses constitution and serve as of the imprinted H19 RNA, brain-specific nonmessenger RNAs, and new tendencies in RNA study. DNLM: RNA, untranslated--genetics.

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Becker's world of the cell by Jeff Hardin, Gregory Paul Bertoni

By Jeff Hardin, Gregory Paul Bertoni

A preview of the mobile -- The chemistry of the cellphone -- The macromolecules of the telephone -- Cells and organelles -- Bioenergetics : the circulation of strength within the cellphone -- Enzymes : the catalysts of existence -- Membranes : their constitution, functionality, and chemistry -- delivery throughout membranes : overcoming the permeability barrier -- Chemotrophic strength metabolism : glycolysis and fermentation -- Chemotrophic strength metabolism : cardio respiratory -- Phototrophic power metabolism : photosynthesis -- The endomembrane procedure and peroxisomes -- sign transduction mechanisms : I. electric and synaptic signaling in neurons -- sign transduction mechanisms : II. messengers and receptors -- Cytoskeletal structures -- mobile circulation : motility and contractility -- past the phone : mobile adhesions, mobile junctions, and extracellular constructions -- The structural foundation of mobile details : dna, chromosomes, and the nucleus -- The phone cycle, dna replication, and mitosis -- Sexual copy, meiosis, and genetic recombination -- Gene expression: I. the genetic code and transcription -- Gene expression: II. protein synthesis and sorting -- The legislation of gene expression -- melanoma cells

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Ribosomes by Alexander S. Spirin (auth.)

By Alexander S. Spirin (auth.)

This e-book is predicated on a sophisticated process lectures on ribosome constitution and protein biosynthesis that I provide on the Moscow kingdom collage. those lectures were a part of a basic direction on molecular biology for nearly 3 a long time, and so they have gone through enormous evolution as wisdom has been professional­ gressing during this box. The growth maintains, and readers can be ready that a few evidence, statements, and ideas integrated within the e-book should be incomplete or out­ of-date. at the least, this can be basically a textbook, yet now not a accomplished overview. It offers a historical past of data and present principles within the box and provides ex­ amples of observations and their interpretations. I take into account that a few interpre­ tations and generalizations could be tentative or disputable, yet i am hoping that this may stimulate considering and discussing larger than if I left white spots. The publication has a prototype: it truly is my monograph "Ribosome constitution and seasoned­ tein Biosynthesis" released by way of the Benjamin/Cummings Publishing corporation, Menlo Park, California, in 1986. right here i've got primarily stored the previous order of pre­ sentation ofthe subject matters and the subdivision into chapters. The contents ofthe chap­ ters, although, were considerably revised and supplemented. The newly writ­ ten chapters on translational keep watch over in prokaryotes (Chapter sixteen) and eukaryotes (Chapter 17) are added.

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DNA Structures Part A: Synthesis and Physical Analysis of by John N. Abelson, Melvin I. Simon, David M.J. Lilley, James

By John N. Abelson, Melvin I. Simon, David M.J. Lilley, James E. Dahlberg

To appreciate the buildings and dynamics of DNA and its interactions with ligands, a whole research of its confirmational flexibility is needed. This quantity and its significant other, quantity 212 of Methods in Enzymology, collate in a single resource all of the tools and ways had to accomplish that aim

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Fibrous Proteins: Amyloids, Prions and Beta Proteins by John M. Squire, David A.D. Parry, Andrey Kajava

By John M. Squire, David A.D. Parry, Andrey Kajava

Amyloids, Prions and Beta Proteins is the final quantity of the three-part thematic sequence on Fibrous Proteins within the Advances in Protein Chemistry serial. Fibrous proteins act as molecular scaffolds in cells supplying the helping constructions of our skeletons, bones, tendons, cartilage, and dermis. They outline the mechanical houses of our inner hole organs similar to the intestines, middle, and blood vessels. This quantity covers such issues as Beta-Structures in Fibrous Proteins; B-Silks: bettering and Controlling Aggregation; Beta-Rolls, Beta-Helices and different Beta-Solenoid Proteins; ordinary Triple B-Stranded Fibrous Folds; constitution, functionality and Amyloidogenesis of Fungal Prions: Filament Polymorphism and Prion editions; X-Ray Fiber and powder Diffraction of PRP Prion Peptides; From the Polymorphism of Amyloid Fibrils to Their meeting Mechanism and Cytotoxicity; Structural versions of Amyloid-like Fibrils.

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The Nucleolus and Ribosome Biogenesis by A.A. Hadjiolov

By A.A. Hadjiolov

The nucleolus had regularly attracted the eye of investigators within the fields of mobile biology and pathology. due to its ubiquitous presence within the nucleus of eukaryotic cells, its quick adjustments in the course of their existence cycle, and its swift reaction to noxious brokers, this organelle has been the topic of a giant variety of reports. but, the precise functionality and the very cause of the life of the nucleolus (the in simple terms huge mobile constitution now not delimited via a membrane) stay mostly unknown. The ribosomes have been came upon quite past due within the research of cells, yet because of their the most important involvement within the protein synthesis equipment of all residing organisms, the elucidation in their constitution and serve as fast grew to become one of many significant objectives of molecular biology. The particularly easy constitution of the ribosome strengthens the desire complete figuring out of the constitution and serve as of this organelle in molecular phrases is in the achieve of up to date examine~ considering all of the rRNA and protein molecules embodied within the ribosome is the fabricated from a different gene, stories at the biogenesis of ribosomes extended swiftly to develop into a middle subject in molecular genetics.

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Protein Physics: A Course of Lectures (Soft Condensed by Alexei V. Finkelstein, Oleg Ptitsyn

By Alexei V. Finkelstein, Oleg Ptitsyn

Protein Physics is a full of life presentation of the main common difficulties of protein constitution, folding and serve as from the physics and chemistry standpoint, in accordance with lectures given by way of the authors. It bargains with fibrous, membrane and, so much of all, with the easiest studied water-soluble globular proteins, in either their local and denatured states. the main elements of protein physics are lined systematically, physico-chemical homes of polypeptide chains; their secondary buildings; tertiary buildings of proteins and their category; conformational transitions in protein molecules and their folding; intermediates of protein folding; folding nuclei; actual backgrounds of coding the protein constructions by way of their amino acid sequences and protein features in terms of the protein constitution. The booklet may be of curiosity to undergraduate and graduate point scholars and researchers of biophysics, biochemistry, biology and fabric technology. * Designed for a large viewers of undergraduate and graduate scholars, in addition to being a reference for researchers in academia and undefined* Covers the main normal difficulties of protein constitution, folding, and serve as and introduces the most important techniques and theories* bargains with fibrous, membrane and particularly water-soluble globular proteins, in either their local and denatured states* Summarizes and offers in a scientific shape the result of numerous a long time of global vast basic examine on protein physics, constitution and folding * Examines experimental facts on protein constitution within the post-genome period

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Physical Biology of the Cell by Rob Phillips

By Rob Phillips

Actual Biology of the mobilephone is a biophysics textbook that explores how the elemental instruments and insights of physics and arithmetic can light up the examine of molecular and telephone biology. Drawing on key examples and seminal experiments from cellphone biology, the ebook demonstrates how quantitative versions may help refine our figuring out of current organic info and in addition be used to make necessary predictions. The booklet blends conventional types in cellphone biology with the quantitative technique standard in physics, to be able to introduce the reader to either the chances and bounds of the rising box of actual biology. whereas educating actual version development in cellphone biology via a realistic, case-study process, the textual content explores how quantitative modeling can be utilized to construct a extra profound, intuitive knowing of mobile biology.

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Imaging Life: Biological Systems from Atoms to Tissues by Gary C. Howard, William E. Brown, Manfred Auer

By Gary C. Howard, William E. Brown, Manfred Auer

This quantity offers an outline of a number of techniques to organic picture research, which permit for the examine of dwelling organisms in any respect degrees of complexity and association. those organisms variety from person macromolecules to subcellular and mobile volumes, tissues and microbial groups. this sort of «systems biology» realizing of existence calls for the combo of a number of imaging thoughts, and with it an in-depth realizing in their respective strengths and barriers, in addition to their intersection with different suggestions. Howard, Brown, and Auer convey us that the mixing of those imaging concepts will let us conquer the reductionist method of biology that ruled the 20th century, which was once aimed toward studying the actual and chemical houses of lifes ingredients, one macromolecule at a time. notwithstanding, whereas in accordance with the legislation of physics and chemistry, existence isn't easily a suite of chemical reactions and actual forces it positive aspects a stupendous spatiotemporal association that permits an inconceivably huge variety of chemical procedures to coexist, subtle by way of billions of years of evolutionary experimentation.
And but, many basic questions stay principally unanswered Imaging lifestyles argues that we're simply now commencing to deal with the spatiotemporal organizational element of residing techniques. «Imaging» is required which will exhibit the spatiotemporal relationships among elements, and hence to appreciate organizational guiding ideas of residing platforms. in basic terms via imaging can we have the capacity to decipher the mechanisms and the awesome association that let and maintain the secret of existence. Imaging lifestyles exhibits us how biology is starting to do exactly that.

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Principles of Cloning by Jose Cibelli

By Jose Cibelli

Ideas of Cloning, moment version is the totally revised variation of the authoritative booklet at the technology of cloning. The ebook provides the fundamental organic mechanisms of the way cloning works and progresses to debate present and capability purposes in uncomplicated biology, agriculture, biotechnology, and medication. starting with the background and conception in the back of cloning, the booklet is going directly to research equipment of micromanipulation, nuclear move, genetic amendment, and being pregnant and neonatal care of cloned animals. The cloning of varied species-including mice, sheep, livestock, and non-mammals-is regarded as good. The Editors were occupied with a few breakthroughs utilizing cloning process, together with the 1st demonstration that cloning works in differentiated cells performed by means of the Recipient of the 2012 Nobel Prize for body structure or medication - Dr John Gurdon the cloning of the 1st mammal from a somatic mobile - Drs Keith Campbell and Ian Wilmut the demonstration that cloning can reset the organic clock - Drs Michael West and Robert Lanza the demonstration terminally differentiated telephone may give upward push to an entire new person - Dr Rudolf Jaenisch and the cloning of the 1st transgenic bovine from a differentiated telephone - Dr Jose Cibelli. the vast majority of the contributing authors are the central investigators on all of the animal species cloned thus far and are expertly certified to give the state of the art info of their respective areas.
- First and such a lot accomplished publication on animal cloning, a hundred% revised
- Describes an in-depth research of present obstacles of the expertise and study components to explore
- deals cloning functions on easy biology, agriculture, biotechnology, and drugs

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